Fixation of biological specimens
نویسنده
چکیده
Fixation is usually the first step to prepare biological specimens for microscopy. Any treatment which will preserve cell structure and its biochemical composition can be deemed to be fixation. Of course, the quality of fixation is the key for all following steps which are necessary in histological research. Hence, preservation of cells with minimal alteration of morphology and virtually no loss of molecules is essential in tissue preservation. In this sense, tissue fixation has to preserve the cells in as life-like a state as possible. Moreover, fixation should protect biological specimens from the denaturing effects of dehydration and all further processings.
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